| Determination of the stability constant of mixed ligand complex of Creatinine and L-Asparagine with Zn+2 by the Potentiometric method |
| کد مقاله : 1032-CNF (R1) |
| نویسندگان: |
|
علیرضا سردشتی *1، حامد داوری شهری2 1زاهدان- دانشگاه سیستان و بلوچستان-دانشکده علوم گروه شیمی 2زاهدان- دیبر اموزش و پرورش |
| چکیده مقاله: |
| Creatinine is an important biological molecule, with many empirical studies of its physical and chemical properties in solutions, especially solids. The presence of several donor groups in its main tautomer form shows that strong coordination capacity. For this reason, a recent study of the bio-ligand complex has been studied. Creatinine in clinical chemistry well Recognized, its level in the blood serum and urine specimen’s indicative of the renal function. In this research work using the potentiometric titration technique in a aqueous solution containing mixed ligand (0.001 M Creatinine+0.001 M L-Asparagine) and 0.002 M(NO3) Zn in ionic strength of 0.11 M (kept constant with KC104) at 25°C by 0.1 M NaOH. The times necessary to reach equilibrium were determined by following the changes in a solution containing metal ion in the presence of a quantity of Creatinine and Asparagine in H+ form.To be reproducible and reliable, this titration had to be performed over a sufficiently long time (6 hours).Several curves were obtained to ensure the reproducibility of the results. An example is given in figure 1.The stability constants of Zn-Creatinine complex (pKc=-5.432) and Zn-L-Asparagine complex (pKc=-4.982), stability constants of mixed ligand complex (Creatinine+ L-Asparagine) with Zn+2 (pKc=-5.316), by the logarithmic analysis of potentiometric titration curve [pH= F (mL of NaOH)] was determined (Figure 2). Comparison of the results shows the Zn-mixed ligand complex and Zn-Creatinine complex more stable than Zn-L-Asparagine complex. The procedure for the formation of such complex bio-ligands is used Creatinine and Asparagine are found in the blood. |
| کلیدواژه ها: |
| Mixed ligand (Creatinine+L-Asparagine) complex, potentiometric titration technique, Logarithmic analysis, Complex stability constant |
| وضعیت : چکیده برای ارائه به صورت پوستر پذیرفته شده است |