| Cu-Ceo2 Nanocomposite Modified Carbon Paste Electrode as an Electrochemical Sensor for Detection of 5-Fluorouracil Anticancer Drug |
| کد مقاله : 1054-CNF |
| نویسندگان |
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محمد وزان *1، جواد تشخوریان1، بهزاد حقیقی2 1دانشگاه شیراز , دانشکده علوم , بخش شیمی , گروه شیمی تجزیه 2دانشگاه شیراز ، دانشکده علوم ، بخش شیمی ، گروه شیمی تجزیه |
| چکیده مقاله |
| Abstract 5-Fluorouracil is a common anticancer drug that is used to treat a wide range of cancers. Continuous monitoring is required to keep the concentration of 5-FU in human fluids at an optimal level [1]. For the detection of 5-FU drug in pharmaceuticals and biological samples, various analytical techniques have been reported, including capillary electrophoresis, fluorescence spectrometry, HPLC, GC-MS, microbiological assays and, voltammetric methods [2,3]. Modern electrochemical techniques are powerful tools for the investigation of medicines and pharmaceuticals in biological matrices and pharmaceutical formulations due to their high sensitivity, selectivity, fast analysis time, low detection limits, simplicity, low sample volume requirements, high reproducibility, and low-cost analysis [4]. The integration of nanoscience and electrochemistry has had a notable impact on the development of electrochemical sensors. For instance, copper and cerium oxide nanoparticles because of their exceptional properties have significant consideration in generating high-sensitive electrochemical sensors and biosensors [5]. In this work, we synthesized Cu-CeO2 nanocomposite by a simple hydrothermal process. Synthesized Cu-CeO2 nanocomposite is characterized by SEM and XRD analysis. Afterward, a stable and efficient electrochemical sensor based on Cu-CeO2 nanocomposite was fabricated for sensitive determination of 5-FU by modification of carbon paste electrode. The electrochemical sensor was evaluated using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The fabricated sensor showed remarkable electrocatalytic activities towards 5-FU thanks to the high conductivity and large surface area provided by the Cu-CeO2 nanocomposite. Important parameters such as pH, the amount of the modifier, pulse amplitude, pulse width, and step increment were investigated and optimized. Under optimal conditions, obtained calibration curve using DPV was linear in the range of 0.1–20 μM, with a detection limit of 8.70 × 10 -8 M. High sensitivity, reproducibility and repeatability with RSD values of 3.6% and, 2.3%, also a good stability with simple fabrication process are all features of this sensor. All the advantages obtained with the fabricated electrochemical sensor confirm that the Cu-CeO2 nanocomposite-based sensor can be applied for selective detection of antileukemic drug 5-fluorouracil. |
| کلیدواژه ها |
| 5-Fluorouracil, Modified Carbon Paste Electrode, Electrochemical Sensor, Nanocomposite |
| وضعیت: چکیده برای ارائه به صورت پوستر پذیرفته شده است |