| Electrochemical sensor based on ZnO nanoflower for simultaneous detection of sertraline and imipramine |
| کد مقاله : 1094-CNF |
| نویسندگان: |
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رضا زعیم باشی *، طیبه شمس پور، علی مصطفوی دانشگاه شهید باهنر کرمان، دانشکده علوم، بخش شیمی |
| چکیده مقاله: |
| Depression is a mood disorder characterized by persistently low mood and a feeling of sadness and loss of interest. A depressed mood is a normal temporary reaction to life events such as loss of a loved one. It is also a symptom of some physical diseases and a side effect of some drugs and medical treatments [1,2]. Tricyclic antidepressants (TCAs) are one of the groups of these drugs that are used as the reference for the treatment of psychiatric disorders, mainly, major depressions [3]. Imipramine is often referred to as tricyclic antidepressant. Studies have indicated that the efficacy of this drug in alleviating depression at night is due to the enhancement of noradrenergic activity through the blockage of norepinephrine reuptake in blocking peripheral and central noradrenergic system. Apart from its therapeutic effect it may because negative side effects such as: convulsions, paresthesia, hallucinations, delusions. Therefore, choosing the proper therapeutic dose is one of the most important elements of a treatment [4]. Sertraline is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is primarily used for major depressive disorder, obsessive–compulsive disorder, panic disorder, and social anxiety disorder. Effectiveness is similar to other antidepressants. Common side effects include diarrhea, sexual dysfunction, and troubles with sleep. Serious side effects include an increased risk of suicide in those less than 25 years old and serotonin syndrome [5]. Electrochemical methods are more desirable than other techniques because they are convenient and low cost. The screen-printed electrodes (SPEs) have been designed especially for miniaturization of electrochemical analytical systems. SPEs are highly-versatile, easy to use, cost-effective analytical tools, also suitable to miniaturization. The modified electrode has good electro catalytic activity, sensitivity, and selectivity; it has also a low detection limit compared to unmodified electrodes. Modified electrodes have been adopted as a promising way to facilitate the direct electron transfer of biomolecules [6-8]. In the present work, we synthesized ZnO nanoflowers and graphite screen printed electrodes were modified with ZnO nanoflowers in order to determination of sertraline and imipramine. ZnO nanoflowers modified graphite screen printed electrode (ZnO-NF/GSPE) displayed excellent electrochemical catalytic activities towards sertraline and imipramine. The oxidation over potentials of imipramine and sertraline were decreased significantly compared with those obtained at the bare graphite screen printed electrode. Differential pulse voltammetry was used for the simultaneous determination of sertraline and imipramine. The peak separation between sertraline and imipramine was 200 mV. imipramine has been sensitively determined with the linear ranges between 0.1–550.0 µM and LOD equal to 0.035 µM (S/N=3). With good selectively and sensitivity, the present method was applied to the determination of sertraline and imipramine in injectable medicine and urine sample |
| کلیدواژه ها: |
| Sertraline. Imipramine. ZnO nanoflowers. Graphite screen printed electrode |
| وضعیت : چکیده برای ارائه به صورت پوستر پذیرفته شده است |