| Fabrication of a biosensor for determination of glucose using modified electrode with Cu and Ni nanoparticles |
| کد مقاله : 1104-CNF |
| نویسندگان |
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فائزه ابراهیمی *1، عمادالدین امین صدرآبادی2، علی بنویدی1 1گروه تجزیه- دانشکده علوم- دانشگاه یزد- یزد- ایران 2گروه تجزیه-دانشکده علوم-دانشگاه یزد-یزد-ایران |
| چکیده مقاله |
| Since accurate measurement of blood glucose is the simplest and most effective way to prevent severe damage from diabetes, the construction of glucose biosensors with high sensitivity and accuracy and low cost has been one of the most important goals of researchers in recent decades[1]. With the advent and development of nanotechnology, the technology of making biosensors has also made significant progress. In this regard, nanostructures based on metal oxides and their composites have excellent properties that can be used for non-enzymatic electrochemical measurement of glucose[2]. Due to the suitable properties of carbon nanofibers (CNF) in electron transfer[3], in the present study, carbon nanofibers have been used as a conductive material to improve the surface of the electrode and also to improve the conductivity of the electrode. Copper oxide and nickel oxide nanoparticles were also used as direct glucose oxidizers[4]. In order to prepare the electrode, first a thin layer of CNF was placed on the glassy carbon electrode (GCE) by dropping and then copper and nickel nanoparticles were synthesized by chronoamperometry on the surface of the modified electrode. In the next step, the fabricated electrode was immersed in a 0.1 M NaOH solution and repeatedly scanned with Cyclic voltammetry (CV) under the potential range from -0.50 to +0.30V at 100 mVs-1 until a stable condition is reached [5]. At this stage, copper oxide and nickel oxide nanoparticles are deposited on the electrode surface. Scanning electron microscopy (SEM) technique was used to characterize the structure of CNF and copper oxide and nickel oxide composites.The electrochemical activity of the fabricated electrode relative to glucose oxidation was studied using Cyclic voltammetry (CV), Differential pulse voltammetry (DPV) and Chronoamperometry, and a fast response (2 s) and a low detection limit (0.1 μM) were observed. |
| کلیدواژه ها |
| Biosensor, Electrochemical sensor, Glucose, CNF, Nanoparticle |
| وضعیت: چکیده برای ارائه به صورت پوستر پذیرفته شده است |